Choline chloride

Polifar Choline Chloride For Feed Additive

Choline chloride is an organic substance with the chemical formula C5H14ClNO, white hygroscopic crystals, odorless and fishy odor. Melting point 305 ℃. 10% aqueous solution pH5-6, unstable in lye. This product is easily soluble in water and ethanol, but insoluble in ether, petroleum ether, benzene, and carbon disulfide. For the treatment of fatty liver and cirrhosis. It is also used as a livestock feed additive, which can stimulate the ovaries to produce more eggs and increase the weight of livestock and fish. In addition, it is a highly effective nutritional supplement and fat-removing agent in food.

Why Use Choline Chloride

Choline chloride is used as a feed additive to stimulate the ovaries of animals to produce more eggs, improve farrowing rates, and increase the weight of livestock and fish. If there is not enough choline in animal feed, animals will develop choline deficiency. The following problems will occur:


Slow growth, reduced egg production, reduced size, and reduced hatchability of eggs. Fat accumulation in the liver and kidney, hepatic steatosis, tendinopathy, behavioral disorders, muscular dystrophy.


Slow growth, behavioral disturbances, neurological disorders, muscular dystrophy, poor fertility, excess fat storage in the liver.


Breathing disturbances, behavioral disturbances, loss of appetite, slowed growth.


Slow growth, fatty liver, poor feeding efficiency, renal and intestinal bleeding.

Specification Of Choline Chloride

Product name Choline Chloride 60% on Corn Cob
Formula HOCH2CH2N(CH3)3Cl
CAS No 67-48-1
Testing Item Standard Result
Appearance Yellow-Brown dry Free Flowing Particles Positive
Carrier Bran Confirmed
Choline Cl Content ≥60% 61.80%
Loss of Drying ≤4 .0% 0.60%
Particle Size(USBS#20) 90% pass 800un mesh Confirm
Trimethylamine ≤300PPM 128PPM
Heavy Metal (Pb) ≤20PPM Not detected

Benefits Of Choline Chloride

  • Promote the recombination
    Promote the recombination of amino acids and improve the utilization of amino acids, especially the essential amino acid methionine in animals.
  • Enhance the physique
    Enhance the physique and resistance of livestock and poultry, and promote growth
  • Improve egg production rate
    Improve egg production rate of laying hens​​​​​​​
Choline Chloride

Structure & Storage Of Choline Chloride

The storage temperature of choline chloride solution should not be lower than -12℃ to avoid blocking the pipeline after crystallization.
Choline chloride powder should be stored in silos with dehumidification equipment to prevent the product from absorbing moisture. Choline chloride powder absorbs moisture and can cause the product to become wet and clumpy, leading to catheter blockage. Plant carrier-type choline chloride powder may be fermented after long-term moisture absorption.

Manufacturing Process Of Choline Chloride

Ethylene oxide method

It is derived from the reaction between trimethylamine and ethylene oxide.
The trimethylamine ethanol solution was added to the reaction pot, and ethylene oxide was introduced into it at about 30°C, and the reaction was stirred for 4 hours, and then neutralized with hydrochloric acid (controlling pH 6.5-7.0). The crude product yield can reach 98%. After decolorization with activated carbon and vacuum concentration, a 70% aqueous solution can be obtained. Add corncob flour, rice husk flour, bran or diatomaceous earth, and other excipients to the aqueous solution to obtain 50% powder.

Chloroethanol method

Substitute ethylene oxide and hydrochloric acid with chloroethanol, and react with trimethylamine under the catalysis of a small amount of ethylene oxide or an alkaline substance: first add 100 parts of chloroethanol to the reaction kettle, add 130 parts of trimethylamine from the liquid surface, Simultaneously, 1.7 parts of ethylene oxide was introduced to initiate the reaction. After adding, it was kept at 32-38°C and stirred for 4h, the yield was 84% (calculated in chloroethanol). If catalyzed by alkaline substances (such as quaternary ammonium salts), the single-pass conversion rate can reach more than 97%.
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