Choline chloride

Polifar Choline Chloride For Feed Additive

Choline chloride is an organic substance with the chemical formula C5H14ClNO, white hygroscopic crystals, odorless and fishy odor. Melting point 305 ℃. 10% aqueous solution pH5-6, unstable in lye. This product is easily soluble in water and ethanol, but insoluble in ether, petroleum ether, benzene, and carbon disulfide. For the treatment of fatty liver and cirrhosis. It is also used as a livestock feed additive, which can stimulate the ovaries to produce more eggs and increase the weight of livestock and fish. In addition, it is a highly effective nutritional supplement and fat-removing agent in food.

Why Use Choline Chloride

Choline chloride is used as a feed additive to stimulate the ovaries of animals to produce more eggs, improve farrowing rates, and increase the weight of livestock and fish. If there is not enough choline in animal feed, animals will develop choline deficiency. The following problems will occur:


Slow growth, reduced egg production, reduced size, and reduced hatchability of eggs. Fat accumulation in the liver and kidney, hepatic steatosis, tendinopathy, behavioral disorders, muscular dystrophy.


Slow growth, behavioral disturbances, neurological disorders, muscular dystrophy, poor fertility, excess fat storage in the liver.


Breathing disturbances, behavioral disturbances, loss of appetite, slowed growth.


Slow growth, fatty liver, poor feeding efficiency, renal and intestinal bleeding.

Specification Of Choline Chloride

Product name Choline Chloride 60% on Corn Cob
Formula HOCH2CH2N(CH3)3Cl
CAS No 67-48-1
Testing Item Standard Result
Appearance Yellow-Brown dry Free Flowing Particles Positive
Carrier Bran Confirmed
Choline Cl Content ≥60% 61.80%
Loss of Drying ≤4 .0% 0.60%
Particle Size(USBS#20) 90% pass 800un mesh Confirm
Trimethylamine ≤300PPM 128PPM
Heavy Metal (Pb) ≤20PPM Not detected

Benefits Of Choline Chloride

  • Promote the recombination
    Promote the recombination of amino acids and improve the utilization of amino acids, especially the essential amino acid methionine in animals.
  • Enhance the physique
    Enhance the physique and resistance of livestock and poultry, and promote growth
  • Improve egg production rate
    Improve egg production rate of laying hens​​​​​​​
Choline Chloride

Structure & Storage Of Choline Chloride

The storage temperature of choline chloride solution should not be lower than -12℃ to avoid blocking the pipeline after crystallization.
Choline chloride powder should be stored in silos with dehumidification equipment to prevent the product from absorbing moisture. Choline chloride powder absorbs moisture and can cause the product to become wet and clumpy, leading to catheter blockage. Plant carrier-type choline chloride powder may be fermented after long-term moisture absorption.

Manufacturing Process Of Choline Chloride

Ethylene oxide method

It is derived from the reaction between trimethylamine and ethylene oxide.
The trimethylamine ethanol solution was added to the reaction pot, and ethylene oxide was introduced into it at about 30°C, and the reaction was stirred for 4 hours, and then neutralized with hydrochloric acid (controlling pH 6.5-7.0). The crude product yield can reach 98%. After decolorization with activated carbon and vacuum concentration, a 70% aqueous solution can be obtained. Add corncob flour, rice husk flour, bran or diatomaceous earth, and other excipients to the aqueous solution to obtain 50% powder.

Chloroethanol method

Substitute ethylene oxide and hydrochloric acid with chloroethanol, and react with trimethylamine under the catalysis of a small amount of ethylene oxide or an alkaline substance: first add 100 parts of chloroethanol to the reaction kettle, add 130 parts of trimethylamine from the liquid surface, Simultaneously, 1.7 parts of ethylene oxide was introduced to initiate the reaction. After adding, it was kept at 32-38°C and stirred for 4h, the yield was 84% (calculated in chloroethanol). If catalyzed by alkaline substances (such as quaternary ammonium salts), the single-pass conversion rate can reach more than 97%.
Related Product News
Discover Food Innovation with Polifar at IFT Food Expo
June 30, 2024

We are very excited to announce that Polifar will participate in the upcoming IFT Expo in Chicago from June 2 to 6, 2024. As a professional supplier of feed additives and food ingredients, we sincerely invite you to visit our booth.

IFT First 2024.jpg
View More
Polifar Pig Premixes: Ensuring Nutrition at Every Growth Stage
July 12, 2024

Pig premixes are a blend of essential vitamins, minerals, amino acids and other nutrients designed to enhance the overall health and growth of pigs. It is an important component of the pig farming industry, ensuring that pigs receive balanced nutrition for increased growth rates, improved immunity and improved feed conversion efficiency.

Natural Sweeteners: A Healthier Alternative to Sugar
July 06, 2024

Introduction With the increasing awareness of the health risks associated with excessive sugar consumption, many people are seeking healthier alternatives. Natural sweeteners have emerged as a popular choice, offering a range of benefits while providing the sweetness we crave.

Trisodium Phosphate: Essential Guide for Food Manufacturers
June 21, 2024

Food additives play a crucial role in modern food production, ensuring quality, taste, and safety. One such additive is Trisodium Phosphate (TSP). This essential guide will delve into the characteristics, applications, benefits, and safety regulations of TSP, providing food manufacturers with comprehensive knowledge about this versatile compound.

We aim to be a reliable partner for customers, distributors, and end users. If you are interested in choline chloride or other feed additives, leave your contact information and requirements, and Polifar will provide you with scientific and effective solutions.
Contact Us
If you need food ingredients, feed additives, or feed premix, please feel free to contact us. We have an excellent technical team, which can be designed according to customers' requirements.
  • Feed Additives:86-25-83463431
    Food Additives:86-25-84431783
  • Feed
  • Head Office: Room 512, Building B-1, Greenland Window Business Plaza, No. 2 Jinlan Road, Jiangning District, Nanjing

    Guangzhou Branch Office: Room 801, Deshun Building, No. 70, Huizhi 3rd Road, Panyu District, Guangzhou
Welcome to contact us​​​​​​​
We have an excellent technical team.
Contact Us
Follow Us
Copyright © 2021 Polifar Group. All rights reserved.   Privacy Policy